What can you do to make it harder for Conflicker?

A very good article mentioning what Conflicker attempts to do and how one could make life harder for Conflicker. Good advice:

First and foremost, if the user of the desktop that is being attacked is NOT a member of the local Administrators group, the worm will have a tough time infecting the computer

Even in Vista. Many advice in this article is for the Vista. To turn off Autoplay please refer to this support article.